Human brain mechanisms of pain perception and regulation in health and disease (Fragment)

Vania Apkarian a,*, M. Catherine Bushnell b, Rolf-Detlef Treede c, Jon-Kar Zubieta d a Department of Physiology, Northwestern University Medical School, 303 E. Chicago Avenue, Ward 5-003, Chicago, IL 60611, USA b Department of Anesthesia, McGill University, Montreal, Canada c Institute of Physiology and Pathophysiology, Johannes Gutenberg University, Mainz, Germany d Department of Psychiatry and…

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Pain and the Neuromatrix in the Brain (Fragment)

Ronald Melzack, Ph.D. Abstract The neuromatrix theory of pain proposes that pain is a multidimensional experience produced by characteristic “neurosignature” patterns of nerve impulses generated by a widely distributed neural network—the “body-self neuromatrix”—in the brain. These neurosignature patterns may be triggered by sensory inputs, but they may also be generated independently of them. Acute pains…

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