Age, Experience and the Changing Brain (Fragment)

BRYAN KOLB*, MARGARET FORGIE, ROBBIN GIBB, GRAZYNA GORNY AND SHARON ROWNTREE Department of Psychology, University of Lethbridge, Lethbridge, Alberta T1K 3M4, Canada. INTRODUCTION In principle, there are two ways that experience could alter the brain: either by modifying existing circuitry or by creating novel circuitry (63). It is reasonable to suppose that the brain makes…

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Activity-Dependent Dendritic Targeting of BDNF and TrkB mRNAs in Hippocampal Neurons (Fragment)

Enrico Tongiorgi, Massimo Righi, and Antonino Cattaneo International School for Advanced Studies (SISSA), Neuroscience Program, 34014 Trieste, Italy. The mechanisms underlying the subcellular localization of neurotrophins and their receptors are poorly understood. We show that in cultured hippocampal neurons, the mRNAs for BDNF and TrkB have a somatodendritic localization, and we quantify the extent of…

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Plasticity in the intrinsic excitability of cortical pyramidal neurons (Fragment)

Niraj S. Desai, Lana C. Rutherford and Gina G. Turrigiano; Department of Biology and Center for Complex Systems, Brandeis University, 415 South Street, Waltham, Massachusetts 02454-9110, USA During learning and development, the level of synaptic input received by cortical neurons may change dramatically. Given a limited range of possible firing rates, how do neurons maintain…

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Cellular Basis of Working Memory (Fragment)

S, Goldman-Rakic, Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510 In the presence of normal sensory and motor capacity, intelligent behavior is widely acknowledged to develop from the interaction of short- and long-term memory. While the behavioral, cellular, and molecular underpinnings of the long-term memory process have long been associated with…

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