Muscle β1D Integrin Reinforces the Cytoskeleton–Matrix Link: Modulation of Integrin Adhesive Function by Alternative Splicing (Fragment)

Alexey M. Belkin, S. Francesco Retta. Department of Cell Biology and Anatomy, University of North Carolina at Chapel Hill, North Carolina 27599. Abstract. Expression of muscle-specific b 1D integrin with an alternatively spliced cytoplasmic domain in CHO and GD25, b 1 integrin-minus cells leads to their phenotypic conversion.B 1D-transfected nonmuscle cells display rounded morphology, lack…

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Reversible unfolding of fibronectin type III and immunoglobulin domains provides the structural basis for stretch and elasticity of titin and fibronectin (Fragment)

HAROLD P. ERICKSON Departmento of Cell Biology, Duke University Medical Center, Durham, NC 27705 ABSTRACT The elastic protein titin comprises a tandem array of fibronectin type m and immunoglobulin domains, which are structurally similar 7-strand fl-sandwiches. A proposed mechanism for stretching titin, by sequential denaturation of individual fibronectin type II-immunoglobulin domains in response to applied…

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